Data/hora: 20/05/2024 05:33:35

Provedor de dados: 	65	
País: 	Brazil	
Título: 	Topical and intraluminal Carolina Rinse Solution in p44/42 and p38 MAP Kinase activation profile in rabbit jejunum after ischemia and reperfusion	
Autores: 	Brandstetter,Luciana Ramos Gaston; Araújo,Eugênio Gonçalves de; Moreno,Juan Carlos Duque; Fioravanti,Maria Clorinda Soares; Moura,Veridiana Maria Brianezi Dignani de; Machado,Patrícia de Almeida.	
Data: 	2014-01-01	
Ano: 	2014	
Palavras-chave: 	ERK 1/2; Intestine; Ischemia; P38; Reperfusion.	
Resumo: 	The effects of topical and intraluminal Carolina Rinse Solution (CRS) in p44/42 (ERK 1/2) and p38 MAPK activation profile, in rabbit jejunum after ischemia and reperfusion (I/R), were investigated in this study. Fifteen New Zealand rabbits were allocated in three groups: Sham-operated (A), Ischemia and reperfusion (B) and CRS (C). Groups B and C were subjected to one hour of ischemia and two hours of reperfusion. In group C, ten minutes prior to reperfusion, the bowel lumen was filled with CRS, and the segment was immersed in CRS until reperfusion onset. Ischemia and reperfusion stimulated the phosphorylation of the p44/42 MAPK and p38 MAPK pathways in some layers of jejunum. Progressive activation of p44/42 MAPK was chiefly localized in the crypts of Lieberkühn, circular and longitudinal muscle layers, whereas p38 MAPK was prominently activated in myenteric plexus and both muscle layers. The results of this research indicate that the chosen model of topical and intraluminal CRS does not interfere in p44/42 and p38 MAPK activation profile in rabbit jejunum subjected to I/R.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782014000100014	
Editor: 	Universidade Federal de Santa Maria	
Relação: 	10.1590/S0103-84782013005000149	
Formato: 	text/html	
Fonte: 	Ciência Rural  v.44 n.1 2014	
Fonte: 	info:eu-repo/semantics/openAccess